Structure of protein may lead to more effective chemotherapy drugs

Scientists at Scripps Research Institute have uncovered the structure of a protein that makes cancer cells resistant to chemotherapy.

During the study, the Scripps scientists along with colleagues from Texas Tech University Health Sciences Centre determined the structure of P-gp using a technique in structural biology known as x-ray crystallography, which involves making crystals of ordered arrays of protein and then blasting the frozen crystals with x-ray radiation.

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